Journal article
Spatiotemporal aeration and lung injury patterns are influenced by the first inflation strategy at birth
DG Tingay, A Rajapaksa, CE Zonneveld, D Black, EJ Perkins, A Adler, B Grychtol, A Lavizzari, IZ Frerichs, VA Zahra, PG Davis
American Journal of Respiratory Cell and Molecular Biology | AMER THORACIC SOC | Published : 2016
Abstract
Ineffective aeration during the first inflations at birth creates regional aeration and ventilation defects, initiating injurious pathways. This study aimed to compare a sustained first inflation at birth or dynamic end-expiratory supported recruitment during tidal inflations against ventilation without intentional recruitment on gas exchange, lung mechanics, spatiotemporal regional aeration and tidal ventilation, and regional lung injury in preterm lambs. Lambs (127 ± 2 d gestation), instrumented at birth, were ventilated for 60 minutes from birth with either lung-protective positive pressure ventilation (control) or as per control after either an initial 30 seconds of 40 cm H2O sustained i..
View full abstractGrants
Awarded by National Health and Medical Research Council Project, Canberra, Australia
Awarded by National Health and Medical Research Council Clinical Career Development Fellowship
Awarded by National Health and Medical Research Council Program
Funding Acknowledgements
This work was supported by National Health and Medical Research Council Project, Canberra, Australia grant 1009287, by the Victorian Government Operational Infrastructure Support Program, by National Health and Medical Research Council Clinical Career Development Fellowship grant 1053889 (D.G.T.), by National Health and Medical Research Council Program grant 606789 (P.G.D.), and by Practitioner Fellowship grant 556600 (P.G.D.).